Jeg har samme personlige erfaring, selv uten FM diagnosen.
http://innhold.legesiden.no/nyheter/nevrologi/hvorfor-opioider-virker-darligere-ved-fibromyalgi
Fibromyalgipasienter responderer ofte dårligere på smertestillende enn anre. Nå viser en ny studie at årsaken kan være lavere binding mellom reseptorer i hjernen og opioider. (The Journal of Neuroscience)I denne studien ble 17 pasienter med fibromyalgi undersøkt med PET-scan (positron emission tomography) og sammenliknet med 17 friske pasienter av samme alder og kjønn. Undersøkelsen viste at fibromyalgipasienter hadde redusert tilgjengelighet av my-opioid reseptorer (MOR) i områder avhjernen assosiert med dempning av smertesignaler.
The underlying neurophysiology of acute pain is fairly well characterized, whereas the central mechanisms operative in chronic pain states are less well understood. Fibromyalgia (FM), a common chronic pain condition characterized by widespread pain, is thought to originate largely from altered central neurotransmission. We compare a sample of 17 FM patients and 17 age- and sex-matched healthy controls, using µ-opioid receptor (MOR) positron emission tomography. We demonstrate that FM patients display reduced MOR binding potential (BP) within several regions known to play a role in pain modulation, including the nucleus accumbens, the amygdala, and the dorsal cingulate. MOR BP in the accumbens of FM patients was negatively correlated with affective pain ratings. Moreover, MOR BP throughout the cingulate and the striatum was also negatively correlated with the relative amount of affective pain (McGill, affective score/sensory score) within these patients. These findings indicate altered endogenous opioid analgesic activity in FM and suggest a possible reason for why exogenous opiates appear to have reduced efficacy in this population
